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Can the Fasting Mimicking Diet Lower Your Biological Age? The Science Says Yes

2 months, 3 weeks ago

2544  0
Posted on Feb 28, 2024, 3 p.m.

Article courtesy of Dr. Joel Kahn, MD, who is a Clinical Professor of Medicine at Wayne State University School of Medicine, one of the world's top cardiologists, a best-selling author, lecturer, and a leading expert in plant-based nutrition and holistic care. He shared a recent interview to bring more attention to important questions and answers for those seeking information regarding his mission, in which he talks about heart health, symptoms, cholesterol, diet, supplements, and much more.

It is no secret that various fasting programs show up in the news over and over. When I discuss diet with my patients, a large number of them skip breakfast and try to eat in a 6–8-hour window. Technically, this is not fasting but a form of "time-restricted eating" or TRE. The overall science for restrictive TRE programs, like eating is not convincing and some studies have identified risks to skipping breakfast.

Another approach is the 5-day fasting-mimicking diet or FMD developed by Valter Longo, Ph.D., and his colleagues. This program can be repeated several months in a row and only involves 5 consecutive days of the month. It is known as PROLON.

New data suggest that the fasting-mimicking diet has important benefits in terms of liver health, immune function, and reversal of measures of aging. 


In mice, periodic cycles of the FMD protect normal cells while killing damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity.

This study performed an analysis of blood samples from a randomized clinical trial using 3 FMD cycles over 3 months in adult study participants. The findings included reduced insulin resistance and other pre-diabetes markers, lower hepatic fat (as determined by magnetic resonance imaging) and increased lymphoid-to-myeloid ratio: an indicator of immune system age.

Based on a validated measure of biological age predictive of morbidity and mortality, 3 FMD cycles were associated with a decrease of 2.5 years in median biological age, independent of weight loss.

 Together these results provide initial support for beneficial effects of the FMD on multiple cardiometabolic risk factors and biomarkers of biological age.


The senior author of the study and world-renowned scientist Valter Longo, Ph.D. commented on this research:

"This study shows for the first time evidence for biological age reduction from two different clinical trials, accompanied by evidence of rejuvenation of metabolic and immune function.

Although many doctors are already recommending the FMD in the United States and Europe, these findings should encourage many more healthcare professionals to recommend FMD cycles to patients with higher than desired levels of disease risk factors as well as to the general population that may be interested in increased function and younger age."

About the author: At his core, Dr. Joel Kahn believes that plant-based nutrition is the most powerful source of preventative medicine on the planet. Having practiced traditional cardiology since 1983, it was only after his own commitment to a plant-based vegan diet that Dr. Kahn truly began to delve into the realm of non-traditional diagnostic tools, prevention tactics, and nutrition-based recovery protocols.

As with anything you read on the internet, this article should not be construed as medical advice; please talk to your doctor or primary care provider before changing your wellness routine. This article is not intended to provide a medical diagnosis, recommendation, treatment, or endorsement. These statements have not been evaluated by the Food and Drug Administration. 

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