Coenzyme Q10 Minimizes Fibromyalgia Symptoms
A recent clinical trial published in March 2013 determined that coenzyme Q10 (CoQ10) improves symptoms in subjects with fibromyalgia. Fibromyalgia is a condition characterized by widespread pain and is estimated to affect over five million American adults.
Twenty subjects with fibromyalgia received 300 mg per day of CoQ10 or a placebo for 40 days. The researchers evaluated the subjects for fibromyalgia symptoms using the Fibromyalgia Impact Questionnaire at the beginning of the study and again after the intervention period. The investigators also assessed inflammation, antioxidant enzymes, mitochondrial biogenesis and gene expression of 5' adenosine monophosphate-activated protein kinase (AMPK), an enzyme that plays a role in cellular energy homeostasis.
The investigators determined that CoQ10 supplementation resulted in a reduction in the Fibromyalgia Impact Questionnaire score compared to placebo, with particular reduction in pain and fatigue and morning tiredness subscales. The researchers also found a reduction in tender points and recovery of inflammation, antioxidant enzymes, mitochondrial biogenesis and AMPK gene expression levels.
The investigators stated, “These results lead to the hypothesis that CoQ10 have a potential therapeutic effect in fibromyalgia, and indicate new potential molecular targets for the therapy of this disease. AMPK could be implicated in the pathophysiology of fibromyalgia.”
Reference:
Cordero MD, et al. Antioxid Redox Signal. 2013 Apr 6.
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