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Hormones & Pharmacological Agents

Sodium Oxybate (Gamma hydroxy butyrate - GHB)

12 years, 11 months ago

1371  0
Posted on Dec 30, 2005, 8 p.m. By Bill Freeman

GENERAL DESCRIPTION: Sodium Oxybate (SO) is one of the more controversial anti-aging drugs available today. Normally referred to as GHB its effects (as well as its reputation) are varied and wide. SO has developed a rather difficult reputation as a drug of abuse. Low to medium doses have been used to treat alcohol withdrawal and as a mild general anesthetic.

GENERAL DESCRIPTION:

Sodium Oxybate (SO) is one of the more controversial anti-aging drugs available today. Normally referred to as GHB its effects (as well as its reputation) are varied and wide. SO has developed a rather difficult reputation as a drug of abuse. Low to medium doses have been used to treat alcohol withdrawal and as a mild general anesthetic. Medium doses may act as a relaxant. At high doses SO may be a potent stimulator of human growth hormone, as well as a very powerful sleep agent. SO has been noted to double concentrations of dopamine in the brain and appears to inhibit the release of dopamine from nerve endings without preventing the manufacture of dopamine. Although not sufficiently studied clinically, SO is reported to have a significant effect on the libido in both men and women.

ROLE IN ANTI-AGING:

SO’s anti-aging benefits may include reduced fat levels, improved muscle mass and condition, deep REM sleep, treatment of insomnia and narcolepsy, improved libido and sexual performance. It acts as a general relaxant and soothing agent.

DEFICIENCY SYMPTOMS: Not applicable

THERAPEUTIC DAILY AMOUNT:

SO is available in liquid form in vials of 10ml, 50mg, 100mg, 30ml, and 140ml under the trade names Alcover, Gamma-oh and Somsanit. Refer to dosage instructions on packaging, or use as directed by a physician.

MAXIMUM SAFE LEVEL:

Do not exceed dosage instructions; overdose of SO requires emergency medical treatment.

SIDE EFFECTS/CONTRAINDICATIONS:

Side effects may include sudden sleep, dizziness, nausea, vomiting, and headaches. At higher doses side effects may include a moderate slowing of the heart, small changes in blood pressure and cardiac and respiratory depression and also, in a few cases, muscle spasms or twitches as the patients enters SO-induced sleep. Patients suffering from Cushing’s disease, convulsions, bradycardia, severe cardiovascular problems, severe hypertension, hyperprolactinemia, epilepsy, narcotic drug dependence, individual hypersensitivity, or who are using depressants should avoid SO. It should not be used with alcohol.

It would be highly advisable to ensure that the patient informs his/her partner about the usage of SO. This will ensure that s/he does not become frightened, if the patient either undergoes muscle spasms/twitches before going into a deep sleep, a sleep from which s/he is unlikely to be aroused for 2 to 4 hours. Unfortunately SO has received a lot of bad press; this is likely due to people using the product in an incorrect manner and under the wrong circumstances. Furthermore, there is concern that since this is a "desired" product,  nderground chemical factories are producing impure, adulterated GHB (a situation which would be dangerous for any substance destined for human consumption).

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