Rapamycin has a major effect on the transcriptome [mouse]
Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazard for mortality.
Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome
Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Perez VI, Richardson A. PLoS One. 2014 Jan 7;9(1):e83988.
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