Posted on Nov 17, 2010, 6 a.m.
Combining green tea polyphenols with alfacalcidol, a form of Vitamin D, helps to strengthen bones, in a lab animal model.
Chronic inflammation is suggested to be a primary factor in progressive bone loss and bone structural deterioration, with oxidative stress and overproduction of pro-inflammatory compounds , most notably tumor necrosis factor-alpha (TNF-alpha). Previous studies have identified certain compounds as having the capacity to inhibit inflammation by suppressing TNF-alpha expression, and thus may offer therapeutic value in the prevention and treatment of chronic inflammation-induced bone loss. Chwan-Li Shen, from Texas Tech University Health Sciences Center (Texas, USA), and colleagues investigated the effects of green tea polyphenols and alfacalcidol, a form of Vitamin D, on bone microstructure and strength along with possible mechanisms in a rat model. The team found that both green tea polyphenols and alfacalcidol individually reversed lipopolysaccharide-induced changes in bone structure, and the combination of nutrients helped to sustain bone micro-architecture and strength. The researchers conclude that: “A rotective impact of [green tea polyphenols]and alfacalcidol in bone microarchitecture during chronic inflammation may be due to a suppression of TNF-alpha.”
Chwan-Li Shen, James K. Yeh, Christina Samathanam, Jay J. Cao, Barbara J. Stoecker, Raul Y. Dagda, Ming-Chien Chyu, Jia-Sheng Wang. “Protective actions of green tea polyphenols and alfacalcidol on bone microstructure in female rats with chronic inflammation.” The Journal of Nutritional Biochemistry, 30 October 2010.