“To lengthen thy life, lessen thy meals.” Starting with those wise words from Benjamin Franklin in 1733, ScienCentral takes a look at the mechanisms of calorie restriction (CR). “Can we find other ways of creating this same state as calorie restriction creates without having to calorie restrict? … CR appears to trigger a gene called Sir (Silent Information Regulator) 2, which seems to be directly linked to prolonging lifespan in different organisms. … Our studies show that, in fact, when you increase Sir2, you live longer; when you block Sir2 from being able to be increased, you can block the calorie restriction response … What we’re trying to achieve is a longer lifespan while maintaining our healthy physiology longer.”
View the Article Under Discussion: http://www.sciencentral.com/articles/view.php3?type=article&article_id=218392437
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