New research into Parkinson's disease is helping scientists better understand some of the mechanisms of this serious and disabling brain disorder, which affects about 1 million people in the United States. Knowledge of the environmental factors and genetics of this illness has allowed investigators to create models of disease that are being used to examine potential causes of neuron disease and to test experimental therapeutics in animals.
New research has revealed that several pesticides can cause Parkinson's disease-like cell damage. Previous research has shown that the pesticide rotenone produces Parkinson's disease-like symptoms and features in rats, and now the new research has shown that other pesticides can also cause this damage.
Further evidence has been found to support the growing body of evidence that Parkinson's disease is linked to environmental factors. Researchers have found that injection of the pesticides, the herbicide paraquat and fungicide maneb resulted in an immediate reduction in the motor activity of mice. Analysis of the mice brains revealed extensive damage to the nigrostriatal system.