Brain Plasticity Restored In Adult Mice

Current immune checkpoint inhibitor therapies are largely ineffective against pancreatic cancer, but that could all change as an immune checkpoint molecule has been identified that could represent a promising immunotherapeutic target for this tumor type, as published in the Proceedings of the National Academy of Sciences.

An epigenetic marker and two genes have been identified that caused heart failure in the offspring and grandchildren of fruits files with high fat diet induced heart dysfunction, which may help to explains how obesity related heart failure is inherited, according to scientists from the Sanford Burnham Prebys Medical Discovery Institute, as published in Nature Communications.

Evidence has been found by University of California scientists of fasting affecting circadian clocks in the liver and skeletal muscle causing them to rewire their metabolism, which can lead to improved health and protection against aging associated diseases, as published in Cell Reports.

Experts claim to be able to predict whether a person can expect to live longer or die sooner than average by looking at an individual’s DNA and analyzing combined effects of genetic variants which influence lifespan, using a scoring system they have created; those in the top 10% of the population may live up to 5 years longer than those who score the lowest, as published in eLife.