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Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors

Restoring the functionality of the neurogenic niche that regulates neural stem cell behavior induces vascular remodeling, culminating in increased neurogenesis and improved olfactory discrimination [mouse]

GDF11  may improve the cerebral vasculature and enhance neurogenesis.

Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL.  Science. 2014 May 9;344(6184):630-4.

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