Posted on Nov 11, 2022, 4 p.m.
University of Sydney researchers have examined whether there are any ongoing ramifications or potential side effects from long-term high protein intake or from consuming certain types of amino acids.
Amino acids have long been touted by the fitness and bodybuilding communities for their muscle-building benefits. From ultra-bulk protein powders to lean mass-promoting snack bars, there’s no shortage of products available for those seeking a muscle boost.
However, protein’s popularity has also meant that less attention has been paid to researching its potential negative side effects.
Published in Nature Metabolism, research led by academics from the University of Sydney’s Charles Perkins Centre, Professor Stephen Simpson and Dr. Samantha Solon-Biet, suggests that while delivering muscle-building benefits, excessive consumption of branched-chain amino acids (BCAAs) may reduce lifespan, negatively impact mood and lead to weight gain.
BCAAs are great for adding muscle mass, but science says you could pay for it later
Dr. Solon-Biet's research has investigated the complex role nutrition plays in mediating various aspects of metabolic health, reproduction, appetite, and ageing.
“While diets high in protein and low in carbohydrates were shown to be beneficial for reproductive function, they had detrimental effects for health in mid-late life, and also led to a shortened lifespan,” she explained.
“What this new research has shown is that amino acid balance is important – it’s best to vary sources of protein to ensure you’re getting the best amino acid balance."
BCAAs could influence mood - and lead to overeating
Using instruments at the University’s core research facility, Sydney Imaging, the research examined the impacts that dietary BCAAs and other essential amino acids such as tryptophan had on the health and body composition of mice.
“Supplementation of BCAAs resulted in high levels of BCAAs in the blood which competed with tryptophan for transport into the brain,” explained the Academic Director of the Charles Perkins Centre's and researcher from the School of Life and Environmental Sciences Professor Stephen Simpson.
“Tryptophan is the sole precursor for the hormone serotonin, which is often called the ‘happiness chemical’ for its mood-enhancing effects and its role in promoting sleep. But serotonin does more than this, and therein lay the problem," he said.
“This then lowered serotonin levels in the brain, which in turn was a potent signal to increase appetite. The serotonin decrease caused by excess BCAA intake led to massive overeating in our mice, which became hugely obese and lived shorter lives.”
Mice were fed double the normal amount of BCAAs (200%), the standard amount (100%), half (50%), or one-fifth (20%) for life. Mice who were fed 200% BCAAs increased their food intake, resulting in obesity and a shortened lifespan.
Increase protein variety for health benefits
Qualified dietitian and public health nutritionist from the University of Sydney's School of Life and Environmental Sciences Dr. Rosilene Ribeiro recommends eating a wide range of proteins.
- It’s important to vary protein sources in order to get a variety of essential amino acids, through a healthy and balanced diet rich in fibre, vitamins and minerals.
- BCAAs are essential amino acids present in protein-containing foods, with red meat and dairy being the richest sources. Chicken, fish, and eggs are also nutritious sources of BCAAs.
- Vegetarians can find BCAAs in beans, lentils, nuts and soy proteins.
- Foods rich in tryptophan include seeds and nuts, soybeans, cheese, chicken, turkey and interestingly, crocodile.
BCAAs are a group of three essential amino acids: leucine, isoleucine and valine, and are most commonly found in red meat and dairy. Whey protein - the most popular form of fitness protein - is made from dairy by-products and contains high levels of BCAA.
As with anything you read on the internet, this article should not be construed as medical advice; please talk to your doctor or primary care provider before changing your wellness routine. This article is not intended to provide a medical diagnosis, recommendation, treatment, or endorsement.
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