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Proposal To Halt The COVID-19 Pandemic With Ivermectin

6 months ago

24388  0
Posted on Jun 03, 2020, 5 p.m.

Proposal To Halt The Covid-19 Pandemic With Ivermectin

Waging War on Covid-19

(Opinion Piece) Article Written by: Karl Hussman, M.D.

Background

Hydroxychloroquine is less effective and has multiple side effects including the possibility of fatal cardiac arrhythmia especially if used in combination with Azithromycin. The safety and efficacy of Hydroxychloroquine for Covid-19 is not confirmed.

A successful vaccine will take a long time to develop; a safe and effective vaccine is not certain. The International Federation of Pharmaceutical Manufacturers and Associations (IFPMA) director Thomas Cueni pointed to estimates that the world will need some 15 billion doses to stop the virus, posing massive logistical challenges. By the time a successful vaccine is invented, tested and distributed, the world must passively wait under mandatory quarantine and social distancing, a strategy which delays but does not halt exponential global contagion. 

With Ivermectin management and possibly a vaccine, Covid-19 cases could be no more dangerous than the flu; business and society could return to normal. 

 Proposed Plan

1) Await results of mass distribution of Ivermectin by Trinidad (they have administered 350,000 doses to all families)..

2) If Covid-19 prevalence in Trinidad is reduced relative to other countries, then Ivermectin should be used as prophylaxis and/or treatment.

3) All governments agree to prioritize production of Ivermectin, subsidizing all pharmacological laboratories to enable Ivermectin synthesis.

4) All governments distribute Ivermectin to the entire world population (as Trinidad did) to be voluntarily taken on the same two consecutive days. 15 billion Ivermectin treatments could be needed (twice for each person spaced 1-2 months apart) in contrast to 15 billion vaccinations estimated to be necessary in order to halt the pandemic.

5) Those later having any symptoms or testing positive for Coronavirus administered Ivermectin; their families quarantined unless the whole family takes Ivermectin.

6) Vitamin D3, zinc, low-dose aspirin encouraged unless contraindicated.

7) Social distancing mandated until pandemic halted.

8) Although Covid-19 may never be fully eradicated, it would cause less global mortality than influenza.

9) Life could fully return to normal if Ivermectin (possibly with doxycycline) is used immediately for all new Covid-19 symptoms.

10) Global ban on any genetic viral manipulation.

Opinion Disclaimer: This article is not intended to provide medical diagnosis, advice, treatment, or endorsement. The views, beliefs, and opinions expressed in this article are those of the author and do not necessarily reflect those of WHN. Any content provided by an author is of their opinion and is not intended to malign any religion, ethic group, club, company, agency, entity, individual, or anyone or anything. As such WHN does not endorse and is not responsible or liable for any content, data, advertising, products, goods or services, statements, information or opinions expressed by the author. 

References:

Hydroxychloroquine

 https://w.ww.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31180-6/fulltext#

The use of hydroxychloroquine/ azithromycin was analyzed in a large multinational study published in Lancet in May 2020 concluded that “the use of a regimen containing hydroxychloroquine or chloroquine (with or without a macrolide) was associated with no evidence of benefit, but instead was associated with an increase in the risk of ventricular arrhythmias and a greater hazard for in-hospital death with COVID-19. The authors suggested that Hydroxychloroquine should not be used outside of clinical trials and urgent confirmation from randomized clinical trials is needed. 

  https://www.documentcloud.org/documents/6933411-Open-Letter-the-Statistical-Analysis-and-Data.html

Findings recently published in Lancet are widely contested. 

  https://www.msn.com/en-us/news/world/us-sends-2-million-doses-of-hydroxychloroquine-to-brazil/ar-BB14Ss2R?ocid=spartandhp

Despite the fact that a small study of Hydroxychloroquine conducted in Brazil was halted because of the risk of fatal heart complications, the USA is sending 2 million doses of that drug to Brazil for health care worker prophylaxis and treatment of infected individuals. 

  https://www.aao.org/eyenet/article/hydroxychloroquine-induced-retinal-toxicity

Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress.

  https://covid.idea.medicine.uw.edu/page/treatment/drugs/hydroxychloroquine-sulfate

Except in the context of a clinical trial, the Panel recommends against the use of the following drugs for the treatment of COVID-19: The combination of hydroxychloroquine plus azithromycin (AIII) because of the potential for toxicities. The U.S. FDA-suggested dose is 800 mg orally on day 1, then 400 mg orally daily for 4-7 days of total treatment, with the total duration based on clinical status.

 https://apple.news/AWzwbjBV5Tf2Cf-TykSmuYA

The World Health Organization announced Monday that it's suspending a trial of hydroxychloroquine in treating COVID-19, saying fears of the drug's potential danger are causing it to "err on the side of caution."

 Ivermectin

 https://www.sciencedirect.com/science/article/pii/S0166354220302011

A single treatment with Ivermectin was able to effect ~5000-fold reduction in SARS-CoV-2 Coronavirus at 48 h in cell culture.

  https://pubmed.ncbi.nlm.nih.gov/12362927/

Ivermectin was generally well tolerated, with no indication of associated CNS toxicity for doses up to 10 times the highest FDA-approved dose of 200 microg/kg. 

  https://www.researchprotocols.org/2016/4/e213/

Ivermectin has a wide therapeutic index and previous studies have shown doses up to 2000 mcg/kg (ie, 10 times the US Food and Drug Administration approved dose) are well tolerated and safe…

 https://www.google.com/amp/s/www.firstpost.com/tech/science/bangladesh-medical-team-says-ivermectin-with-antibiotic-doxycycline-works-to-treat-covid-19-patients-8381321.html/amp

Alam, a reputed clinician in Bangladesh, said a frequently used antiprotozoal medicine called Ivermectin in a single dose with Doxycycline, an antibiotic, yielded virtually the near-miraculous result in curing the patients with COVID-19. My team was prescribing the two medicines only for coronavirus patients, most of them initially reporting with respiratory problems with related complaints, later to be tested COVID-19 positive.

https://www.nytimes.com/reuters/2020/05/19/world/americas/19reuters-health-coronavirus-bolivia-drug.html

Officials in the Bolivian city of Trinidad launched a campaign on Monday to give out free doses of the anti-parasite drug ivermectin in a bid to combat the coronavirus in the country's hard-hit eastern region. Authorities will go house-to-house to pass out some 350,000 doses of the drug to residents in the region of Beni, where Trinidad is the capital. The area has 581 confirmed cases and 41 coronavirus-related deaths.

  https://www.healthline.com/health-news/heres-exactly-where-were-at-with-vaccines-and-treatments-for-covid-19#Clinical-trial-stages

A detailed “fact checked” discussion of the “exact” status of potential treatment strategies for Covid-19 published on Healthine on May 26, 2020 does not mention Ivermectin.

 https://link.springer.com/article/10.1007/s00210-020-01902-5

Ivermectin is an antiparasitic drug that has also shown an effective pharmacological activity towards various infective agents, including viruses. This paper proposes an alternative mechanism of action for this drug that makes it capable of having an antiviral action, also against the novel coronavirus, in addition to the processes already reported in literature.

 https://www.trialsitenews.com/category/essentia-health/

Great Plains Health Systems Investigate Treatment Options for COVID-19 Patients: Ivermectin Study Planned

 https://www.marketwatch.com/press-release/ivermectin-market-2020-global-manufacturing-size-share-investment-opportunities-future-trends-market-impact-revenue-demand-and-analysis-by-forecast-2025-2020-05-26

This report gives a historical overview of the Ivermectin market trends, growth, revenue, capacity, cost structure, and key driver’s analysis. Final Report will add the analysis of the impact of COVID-19 on this industry.

 https://clinicaltrials.gov/ct2/bye/rQoPWwoRrXS9-i-wudNgpQDxudhWudNzlXNiZip9Ei7ym67VZRFnSgCj-g0JA6h9Ei4L3BUgWwNG0it.

Article entitled “The FDA-approved Drug Ivermectin Inhibits the Replication of SARS-CoV-2 in Vitro”

 https://youtu.be/6W3cqiR2C_M

YouTube discussion of Ivermectin (which I enjoyed).

 Potential Vaccine

https://innovationorigins.com/update-vaccine-against-corona-initial-oxford-clinical-trials-are-disappointing/

Oxford University’s first clinical trials with a potential corona vaccine have so far been disappointing. After the publication of the preliminary data, it was the American scientist Bill Haseltine in particular who sharply criticized Oxford University on Forbes.com. According to the university itself, however, some success has definitely been booked. For example, two-thirds of the unvaccinated animals showed clear signs of viral pneumonia when the autopsy was performed. This was not the same case in the vaccinated animals. The conclusion is that although the vaccinated animals were infected – the vaccine failed to protect them – the disease was very clearly less serious. But these results mean that the virus might still be transmissible via people who have been vaccinated this way.

 https://www.cnbc.com/2020/04/09/safety-concerns-over-vaccine-for-coronavirus-still-remain-says-expert.html

While vaccine developments have been accelerated, there are still concerns over safety for a COVID-19 vaccine, according to Jerome Kim, director-general of the International Vaccine Institute. 

  https://www.theatlantic.com/health/archive/2020/02/covid-vaccine/607000/

The Article entitled: “You’re Likely to Get the Coronavirus” Lipsitch predicts that within the coming year, some 40 to 70 percent of people around the world will be infected with the virus that causes COVID-19. But, he clarifies emphatically, this does not mean that all will have severe illnesses. “It’s likely that many will have mild disease, or may be asymptomatic,” he said. As with influenza, which is often life-threatening to people with chronic health conditions and of older age, most cases pass without medical care. (Overall, about 14 percent of people with influenza have no symptoms.) Lipsitch is far from alone in his belief that this virus will continue to spread widely. The emerging consensus among epidemiologists is that the most likely outcome of this outbreak is a new seasonal disease—a fifth “endemic” coronavirus. With the other four, people are not known to develop long-lasting immunity. If this one follows suit, and if the disease continues to be as severe as it is now, “cold and flu season” could become “cold and flu and COVID-19 season.” And coronaviruses could present a particular challenge in that at their core they, like influenza viruses, contain single strands of RNA. This viral class is likely to mutate, and vaccines may need to be in constant development, as with the flu. “If we’re putting all our hopes in a vaccine as being the answer, we’re in trouble,” Jason Schwartz, an assistant professor at Yale School of Public Health who studies vaccine policy, told me. The best-case scenario, as Schwartz sees it, is the one in which this vaccine development happens far too late to make a difference for the current outbreak.

https://news.yahoo.com/pharma-chiefs-see-coronavirus-vaccine-end-challenges-daunting-193407118.html

Pharmaceutical company executives said that one or several COVID-19 vaccines could begin rolling out before 2021, but warned the challenges would be "daunting" as it was estimated that 15 billion doses would be needed to halt the pandemic.

 Additional Therapies

https://www.drugs.com/condition/covid-19.html

Currently, there are no FDA approved treatments for COVID-19.

  https://www.medrxiv.org/content/10.1101/2020.05.01.20086694v2

Preliminary, non-peer reviewed results from 1620 hospitalized patients (authors from Columbia University Medical Center and Mass General): Famotidine (Pepcid) use is associated with reduced risk of intubation or death in hospitalized COVID-19 patients. Randomized controlled trials are warranted to determine whether famotidine therapy improves outcomes in hospitalized COVID-19 patients.



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