Non-Profit Trusted Source of Non-Commercial Health Information
The Original Voice of the American Academy of Anti-Aging, Preventative, and Regenerative Medicine
logo logo
Women's Health GI-Digestive Metabolic Syndrome Weight and Obesity

Promote Metabolic Health with Prebiotics

7 years, 4 months ago

6796  0
Posted on Jul 18, 2014, 6 a.m.

Compounds that support the GI tract, prebiotics may reduce metabolic risk factors, among obese women.

Prebiotics are compounds that help to promote “good bacteria” (probiotics) in the gastrointestinal tract, with which a wide variety of beneficial health effects are associated.   Nuria Salazar, from the Universite Catholique de Louvain (Belgium), and colleagues enrolled 30 obese women to a study in which subjects received a prebiotic supplement (inulin-type fructans, 16 g/day) or placebo (maltodextrin), for 3 months. At the end of the study period, levels of Bifidobacterium and two other probiotics in the GI tract were increased among the prebiotic group.  As well, levels of short chain fatty acids – a potential marker of metabolic dysfunction – were reduced and correlated with BMI.  The prebiotic group also displayed reductions in insulin levels and the homeostasis model assessment (HOMA) – two markers of metabolic syndrome.  Positing that: [prebiotics] modulate Bifidobacterium spp. and decrease fecal [short chain fatty acids] concentration in obese women,” the study authors submit that: “[prebiotics] could lessen metabolic risk factors associated with higher fecal [short chain fatty acids] concentration in obese individuals.”

Nuria Salazar, Evelyne M. Dewulf, Audrey M. Neyrinck, Laure B. Bindels, Patrice D. Cani, Jacques Mahillon, et al.  “Inulin-type fructans modulate intestinal Bifidobacterium species populations and decrease fecal short-chain fatty acids in obese women.”   Clinical Nutrition, 11 June 2014.

WorldHealth Videos