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Alzheimer's Disease Functional Foods Inflammation Neurology

Pomegranate Compound Addresses Neuroinflammation

6 years, 5 months ago

8133  0
Posted on Dec 23, 2015, 6 a.m.

Compound derivatives of punicalagin may lead to a treatment for Alzheimer’s disease.

The pomegranate fruit is an abundant source of punicalagin – a potent polyphenol.  Previous studies suggest an anti-inflammatory effect of punicalagin.  Olumayokun Olajide, from the University of Huddersfield (United Kingdgom), and colleagues observe that punicalagin inhibits inflammation in the brain’s micrologia cells, in a lab animal model. This inflammation leads to the destruction of more and more brain cells, making the condition of Alzheimer's sufferers progressively worse.  Observing that: “These results suggest that punicalagin inhibits neuroinflammation in … microglia through interference with NF-[kappa]B signalling,” the study authors submit that the data “suggest[s]its potential as a nutritional preventive strategy in neurodegenerative disorders.”

Olajide OA, Kumar A, Velagapudi R, Okorji UP, Fiebich BL.  “Punicalagin inhibits neuroinflammation in LPS-activated rat primary microglia.”  Mol Nutr Food Res. 2014 Jul 28.

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