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Plant Fiber Compounds Help to Promote Immune Health

Plant derived polysaccharides may improve the immune response, by modifying certain serum proteins.

Certain studies suggest that dietary carbohydrates may have beneficial functional health effects; specifically  in-vitro and in-vivo studies have proposed that certain dietary saccharide compounds exert immunomodulatory effects, with specific compounds affecting the cellular pathway of serum protein glycosylation – an important enzymatic process in cells that is linked to changes in immune response. Azita Alavi, from St George’s University of London (United Kingdom), and colleagues studied a group of 12 subjects, whose plasma glycan profiles (a marker of glycosylation) were measured prior to consuming a mixed saccharide dietary supplement for a seven-week period.  The team observed striking changes, particularly in the first two weeks of supplementation, concluding that: “Supplementation with the dietary plant-derived polysaccharides …  resulted in significant changes in serum protein N-glycosylation in healthy individuals.”

A Alavi, O Fraser, E Tarelli, M Bland, J Axford.  “An open-label dosing study to evaluate the safety and effects of a dietary plant-derived polysaccharide supplement on the N-glycosylation status of serum glycoproteins in healthy subjects.”  European Journal of Clinical Nutrition, 12 January 2011; doi:10.1038/ejcn.2010.263.

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