HomeAnti-AgingAnti-Aging Research SciencePAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice

May 25, 2014

Anti-Aging Research Science

Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor (SERPIN), is a critical determinant of replicative senescence [in vitro]

Plasminogen activator inhibitor-1 (PAI-1) deficiency retards the development of senescence and protects organ structure and function while prolonging the lifespan.

Eren M, Boe AE, Murphy SB, Place AT, Nagpal V, Morales-Nebreda L, Urich D, Quaggin SE, Budinger GR, Mutlu GM, Miyata T, Vaughan DE. Proc Natl Acad Sci U S A. 2014 Apr 28.