Non-Profit Trusted Source of Non-Commercial Health Information
The Original Voice of the American Academy of Anti-Aging, Preventative, and Regenerative Medicine
logo logo
Anti-Aging Research Science

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice

6 years ago

2822  0
Posted on May 25, 2014, 3 p.m.

Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor (SERPIN), is a critical determinant of replicative senescence [in vitro]

Plasminogen activator inhibitor-1 (PAI-1) deficiency retards the development of senescence and protects organ structure and function while prolonging the lifespan.

Eren M, Boe AE, Murphy SB, Place AT, Nagpal V, Morales-Nebreda L, Urich D, Quaggin SE, Budinger GR, Mutlu GM, Miyata T, Vaughan DE.  Proc Natl Acad Sci U S A. 2014 Apr 28.

WorldHealth Videos

WorldHealth Sponsors