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New Tool For Imprinting Biochips

Technology newly developed from researchers with Advanced Science Research Centeru2019s Nanoscience Initiative may allow more biochemical probes to be fit on to a single biochip, which would decrease costs of screening and analyzing changes associated with disease development, detecting bioterrorism and other areas of research, as published in the journal Chem.

 

To develop a new biochip printing technique combinations of microfluidic techniques with beam pen lithography and photochemical surface reactions were used which involves exposing a biochip’s surface to specific organic reagents, then tightly focused beams of light are used to adhere the immobilized reagents to the chip surface. This technique will allow for repeat exposure of a single chip to the same or different factors and imprint the reactions on to different sections of the biochip, which results in a biochip that can accommodate more probes than is achievable with current platforms.

 

3D printing has taken another step forward with this tool, which is basically a new multi-dimensional nanoscale printer with greater imprint capabilities and greater complexity on the surface of biochip than any technology currently available commercially, that will help researchers to gain a better understanding of how cells and biological pathways work.

 

Another benefit of this development is that it allows a variety of delicate materials to be printed reliably including lipids, glasses, and metals, on the length of scale biological interactions without the need to use a clean room. It also allows for more reactive probes to be fit on a single chip, which could reduce the cost of biochip facilitated research.

 

 

Materials provided by Advanced Science Research Center, GC/CUNY.

Note: Content may be edited for style and length.

Journal Reference:

Carlos Carbonell, Daniel J. Valles, Alexa M. Wong, Mei Wai Tsui, Moussa Niang, Adam B. Braunschweig. Massively Multiplexed Tip-Based Photochemical Lithography under Continuous Capillary Flow. Chem, 2018; DOI: 10.1016/j.chempr.2018.01.020

 

 

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