Inactivation of Yeast Isw2 Chromatin Remodeling Enzyme Mimics Longevity Effect of Calorie Restriction via Induction of Genotoxic Stress Response6 years ago
Posted on May 28, 2014, 3 p.m.
Reduces levels of athp-2, a putative ortholog of Itc1/ACF1 [roundworm]
Deletion of ISW2, or mutations inactivating the Isw2 enzyme complex, extends yeast replicative lifespan. With transcriptome analysis indicating that isw2[delta] partially mimics an upregulated stress response in calorie-restricted cells,, isw2[delta] cells show an increased response to genotoxic stresses.
Dang W, Sutphin GL, Dorsey JA, Otte GL, Cao K, Berger SL, et al. Cell Metab. 2014 May 7. pii: S1550-4131(14)00167-3.