Posted on Feb 26, 2019, 3 p.m.
Aging has been delayed in animal models, and human data shows partial age delay and reversal using existing therapies. Advances in technology and research are driving innovation into fields that affect our ability to live well as we age. Science is making living longer possible, and we are just beginning to realize the opportunities longevity can offer.
Rejuvenate Bio work investigating plans to rejuvenate dogs using gene editing therapy and suggest aging reversal in dogs may been seen in the next few years; if successfully eventually the approach could be used on humans, Dr. George Church may even be one of the first volunteers as he says the idea it to live to 130 in the body of a much younger person. Age reversal has been conducted in a variety of traits including obesity, diabetes, kidneys, and cardiac disease; gene therapy may be able to affect them all simultaneously.
RAADfest by Bill Faloon says it may be possible to reverse aging in humans today, with the largest overall longevity gain found by using a combination of metformin and rapamycin; studies suggest as late as the 70s age may be extended by 20 years based on mouse models, and age reversal tourniquets may transport us to a point where aging can become a manageable condition.
New innovations and interventions may improve the chances of living past current predictions via senolytics, NAD+, sirtuins, mTOR-inhibition, AMPK, umbilical cord, stem cells, plasma/blood, exosomes from younger cells, mesenchymal stem cells, iPSCs, immune restoration, mitochondria transfer, rapamycin, metformin, and CRISPR gene editing technology.
Build a foundation and do some research before embarking on any age reversing strategy, starting with doing an age management blood test panel to reveal any weak links in physiology that may slow down your progress or trip you up in the interim; after which you can talk with an age management physician to identify and clear up any weaknesses you may have. Under an order from our doctor some health insurance companies may pay for some/all/none of the testing. Some labs can charge up to $4000 to run this test, but you can also find it for as little as $695 from some age reversal projects.
Senolytics are new and exciting as they have been shown to help extended healthy lifespans via killing off senescent cells; these zombie cells clog the body and disrupt normal functioning as they do not die, rather hang around to cause problems and up to now there was no way to rid them. Animal studies have demonstrated that senolytics quercetin + dasatinib: improve symptoms of frailty; enhance coat colour appearance; improve arterial/cardiac function; decrease osteoporosis; increase exercise endurance; reduce tremors; reduce urinary incontinence; improve liver/kidney pathologic age scores; and extend healthy lifespan.
NAD+ may be the closest thing to the fountain of youth, and is one of the most important molecule for life as without it life cannot exist, according to David Sinclair. NAD+ is found in young cells and turns off degenerative processes. Re-upping NAD+ in older mice has been found to cause them to look and act younger, as well as live longer than expected. NAD+ may help to improve heart function and restore cellular DNA repair. Every cell in the body suffers 10 DNA breakdowns daily, unrepaired DNA damage is a degenerative aging factor; depletion of NAD+ with age turns off DNA repair enzymes. By the age of 50 NAD+ has decreased by 40%, and by 80 levels drop as much as 98%. NAD+ deficits can impact: depression, tremors, arterial stiffness, circadian rhythm imbalance, restless leg syndrome, sarcopenia, cellular senescence, pro-youth genes silenced, and death. NAD+ can be boosted in those 50+ via infusions or patches; and in those under 50 via supplement of 250-500mg/day of nicotinamide riboside.
A blood panel is essential to combining age reversal therapies which should measure hormones, LDL/HDL, kidney function, vitamin D, insulin, triglycerides, C-reactive protein, homocysteine, glucose, and blood pressure. You should strive to normalize these levels before moving onto therapies such as : stem cell rejuvenation therapy; boosting cellular AMPK; suppressing excess mTORC1; replenishing NAD + cell levels; and activating sirtuin proteins.
Congratulations to all of the biotech companies that are working towards therapies that have a direct impact on human longevity like resTORbio, Osiris Therapeutics, Calico, Rejuvenate Bio, and other startups such as Unity Biotechnology, Juvenescence, Celularity, and Oisin Biotechnologies, among others. It’s encouraging to see the biotech industry catching up to the clinicians, for in the final analysis the lives we save may be our own.
Dr. Ronald Klatz, MD., DO.
President and founder of the American Academy of Anti-Aging Medicine
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