Friday, October 4, 2024

Engineering a memory with [long-term potentiation (LTP) and long-term depression (LTD)]

Optogenetics to provide the first hard evidence that long-term potentiation at brain synapses is crucial for memory formation

Strengthening of synapses by long-term potentiation is required for the formation of fearful memories, but also that weakening of the same synapses by a similar, opposing mechanism can erase the memories.

Nabavi S, Fox R, Proulx CD, Lin JY, Tsien RY, Malinow R.  Nature. 2014 Jun 1.

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