Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B33 years, 11 months ago
Posted on Aug 18, 2014, 2 p.m.
Vitamin B3 compound boosts mitochondria [mouse]
Nicotinamide riboside, a vitamin B3, is effective to delayed early- and late-stage disease progression, via mitochondrial biogenesis in skeletal muscle and brown adipose tissue, thereby preventing mitochondrial ultrastructure abnormalities and mtDNA deletion formation. NR further stimulated mitochondrial unfolded protein response, suggesting its protective role in mitochondrial disease.
Khan NA, Auranen M, Paetau I, Pirinen E, Euro L, Forsstrom S, Pasila L, Velagapudi V, Carroll CJ, Auwerx J, Suomalainen A. EMBO Mol Med. 2014 Apr 6;6(6):721-31.