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Anti-Aging Research Science

Central and peripheral administration of antisense oligonucleotide targeting amyloid-[beta] protein precursor improves learning and memory and reduces neuroinflammatory cytokines in Tg2576 (A[beta]PPswe) mice

5 years, 2 months ago

2190  0
Posted on Jul 21, 2014, 2 p.m.

OL-1 reverses learning and memory impairment, reverses behavioral disinhibition, reduces A[beta]protein precursor, and neuroinflammatory markers [mouse]

Antisense oligonucleotide improves learning and memory, reduces A[beta] protein precursor and cytokine levels, in animals engineered to have increased brain levels of beta amyloid. Antisense reverses the beta amyloid-induced learning and memory deficits.

Farr SA, Erickson MA, Niehoff ML, Banks WA, Morley JE.  J Alzheimers Dis. 2014;40(4):1005-16.

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