Central and peripheral administration of antisense oligonucleotide targeting amyloid-[beta] protein precursor improves learning and memory and reduces neuroinflammatory cytokines in Tg2576 (A[beta]PPswe) mice5 years, 2 months ago
Posted on Jul 21, 2014, 2 p.m.
OL-1 reverses learning and memory impairment, reverses behavioral disinhibition, reduces A[beta]protein precursor, and neuroinflammatory markers [mouse]
Antisense oligonucleotide improves learning and memory, reduces A[beta] protein precursor and cytokine levels, in animals engineered to have increased brain levels of beta amyloid. Antisense reverses the beta amyloid-induced learning and memory deficits.
Farr SA, Erickson MA, Niehoff ML, Banks WA, Morley JE. J Alzheimers Dis. 2014;40(4):1005-16.