Central and peripheral administration of antisense oligonucleotide targeting amyloid-[beta] protein precursor improves learning and memory and reduces neuroinflammatory cytokines in Tg2576 (A[beta]PPswe) mice

Antisense oligonucleotide improves learning and memory, reduces A[beta] protein precursor and cytokine levels, in animals engineered to have increased brain levels of beta amyloid. Antisense reverses the beta amyloid-induced learning and memory deficits.