Sulforaphane, a primary phytochemical found in broccoli, cauliflower and other cruciferous vegetables, is an inhibitor of histone deacetylase, or HDAC enzymes. HDAC inhibition is an emerging field of cancer treatment and represents a promising pharmaceutical and dietary approach. Emily Ho, from Oregon State Un (Oregon, USA), and colleagues have investigated the effects of sulforaphane in normal, benign hyperplasia, and cancerous prostate epithelial cells. The team observed that 15 micromoles of sulforaphane caused cell cycle arrest and apoptosis in benign hyperplasia and cancerous prostate epithelial cells; and did not affect normal cells whatsoever. Sulforaphane also selectively decreased HDAC enzyme activity. The researchers conclude that: “[Sulforaphane] exerts differential effects on cell proliferation, HDAC activity and downstream targets in normal and cancer cells.”
Broccoli Compound Selectively Targets Cancer Cells
Sulforaphane, one of the primary phytochemicals in broccoli and other cruciferous vegetables, selectively targets and kills cancer cells while leaving normal prostate cells healthy and unaffected.
John D. Clarke, Anna Hsu, Zhen Yu, Roderick H. Dashwood ,Emily Ho. “Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells.” Molecular Nutrition & Food Research, 4 March 2011.
RELATED ARTICLES