Posted on Mar 24, 2015, 10 a.m.
This paper presents an update on complex cytokine matrixes from stem cell sources for the mitigation of systemic inflammation and facial regeneration
A group of international investigators have conducted a preliminary study to demonstrate the safety of using a complex cytokine from nonautologous stem cells in the human phenotype. They found significant changes in serum expression in interleukin 1, TNF-alpha, interleukin 6, and interleukin 8 indicating a mitigation of overall systemic inflammation. Subjects and researchers likewise observed ameliorative changes in facial epidermal/dermal complex. Patients reported other antidotal propitious changes.
The intentionality of this limited safety study was to understand side effect, complications, or other deleterious events associated with this treatment strategy. There are no reports of any side effects such as nausea, headaches, fatigue, edema, or joint stiffness. Five patients participated in this limited study, and they stated that there were no negative physiological manifestations which were experienced; and these findings are concordant with utilization of this therapy in other non-human organisms. Subjects were screened by a clinician for any unusual skin abnormalities or regional tumors. Thus, with six months of mild prophylaxis this therapeutic strategy did mollify regional and systemic inflammation, and did not induce any kind of virulent response.
All subjects reported similar optimizing benefits of this treatment strategy. These individuals stated that they felt more energy, younger, higher libido, improvement in executive functions, faster wound healing response, enhanced emotional salubriousness, and greater capacity to exercise. They also reported overall facial rejuvenation; and the skin of the torso was aesthetically enhanced. There was no weight gain; however, subjects stated they were more lean with less body fat, as well as they exhibited a higher degree of muscle mass. These antidotal reports are very promising; however, they need to be further empirically substantiated with more cohorts as well as rigorous biological assays.
Current strategies for systemic facial rejuvenation are limited. The myriad of topical agents have slight effect on epidermal/dermal positive remodeling. The most efficacious lasers such as the fractionated CO2 system utilizes dermal intense heating to induce cellular wound healing response; however, this strategy does not up and down regulate essential genes necessary for propitious changes associated with a robust, all-inclusive anti-aging response. Thus, this cosmetic strategy cannot be executed to continuously reprogram all the cells of the face.
It is not possible that medical clinicians will be able to provide patients with complex cytokine matrix injections to propitiously reverse the pejorative manifestations of aging. The effects of the regenerative therapy may likewise impact musculature, fat deposition, ligaments, tendons, as well as the diverse array of cell types comprising the facial tissue.
This regenerative therapy most likely affects thousands of genes in distinctive cell lines. In the ensuing five years, there will be regenerative strategies from stem cell sources, which will ameliorate protein translation in terms of more youthfully modeling a diverse array of bodily tissues. Regional autologous stem cell injections, as well as IV therapies, may temporarily reduce overall inflammations; and have very limited effectiveness in terms of cellular remodeling as these regenerative cells are quickly differentiated into mature cell lines. This phenomena assuages any kind of medicinal paracrine signaling; and these grafted cells lose their proclivity to reprogram in an auspicious manner tissue dynamics.
Currently this nascent research effort is in its early stage in terms of peptide matrixes from allogeneic stem cell sources to reprogram cellular machinations to where the phenotype in a ubiquitous manner becomes more youthfully optimal rather than virulently senescent. This small proof of safety study has indicated that this medicinal paradigm could be edifying in terms of mollifying the effects of aging or reversing the deleterious paracrine signaling cascades, which disregulates gene transcriptions in an unfavorable manner.
This international research group in the pursuing months intends to enlist more subjects; and stringently employ a diverse array of biomarkers to empirically assess some of the positive antidotal reports stemming from this present study. The phenomena of aging represents a kind of pathogenesis in terms of the disregulation of protein translation. The one trillion cells of the body, due to virulent inteulinkin and paracrine matrixes modify homeostatic protein expression where the gestalt of the phenotype becomes non-optimally disregulated; and some kind of propitious peptide therapy can assuage tissue pathogenesis. Thus, global cellular remodeling therapeutic regime is necessary to optimize tissue dynamic of the older phenotype. This research group’s complex cytokine matrix is presently underpatent for secret formula. Thus, this innovative therapeutic cytokine strategy has been shown to be safe in animal models as well as humans in small proof of concept studies, and it may have remarkable effects in terms of optimizing a diverse array of physiological parameters.
Submitted by Dr. Ron Shane, Regina Woo and Nikki Kimura