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Home » Mitochondria

Severe mitochondrial toxicity.caused by HAART drugs.

By hkugler at Nov. 24, 2011, 2:26 a.m., 10611 hits

An ever increasing number of papers show mitochondrial toxicity of HAART drugs (1, 2, 3).

1) Apostolova N, Blas-García A, Esplugues JV. Mitochondrial interference by anti-HIV drugs: mechanisms beyond Pol-γ inhibition. Trends Pharmacol Sci. 2011 Sep 5. .
2) Apostolova N, Blas-García A, Esplugues JV. Mitochondrial toxicity in HAART: an overview of in vitro evidence. Curr Pharm Des. 2011;17(20):2130-44. PMID: 21718249.
3) Blas-Garcia A, Esplugues JV, Apostolova N. Twenty years of HIV-1 non-nucleoside reverse transcriptase inhibitors: time to reevaluate their toxicity. Curr Med Chem. 2011;18(14):2186-95. Review. PMID: 21521162.

— Last Edited by Hans J. Kugler, PhD at 2011-11-30 21:16:41 —

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