A Low Carbohydrate, High Protein Diet Slows Tumor Growth and Prevents Cancer Initiation.

By BobbyBoomer at Aug. 4, 2011, 2:52 a.m., 20140 hits

From the National Institute of Health (NIH)

A Low Carbohydrate, High Protein Diet Slows Tumor Growth and Prevents Cancer Initiation.
Ho VW, Leung K, Hsu A, Luk B, Lai J, Shen SY, Minchinton AI, Waterhouse D, Bally MB, Lin W, Nelson BH, Sly LM, Krystal G.
Source

Authors' Affiliations: The Terry Fox Laboratory, BC Cancer Research Centre, BC Cancer Agency; Department of Pediatrics, Division of Gastroenterology, BC Children's Hospital & University of British Columbia, Vancouver; Radiation Biology Unit-Department of Integrative Oncology and Department of Experimental Therapeutics, BC Cancer Research Centre, and Deeley Research Centre, BC Cancer Agency, Victoria, British Columbia, Canada.
Abstract

Since cancer cells depend on glucose more than normal cells, we compared the effects of low carbohydrate (CHO) diets to a Western diet on the growth rate of tumors in mice. To avoid caloric restriction-induced effects, we designed the low CHO diets isocaloric with the Western diet by increasing protein rather than fat levels because of the reported tumor-promoting effects of high fat and the immune-stimulating effects of high protein. We found that both murine and human carcinomas grew slower in mice on diets containing low amylose CHO and high protein compared with a Western diet characterized by relatively high CHO and low protein. There was no weight difference between the tumor-bearing mice on the low CHO or Western diets. Additionally, the low CHO-fed mice exhibited lower blood glucose, insulin, and lactate levels. Additive antitumor effects with the low CHO diets were observed with the mTOR inhibitor CCI-779 and especially with the COX-2 inhibitor Celebrex, a potent anti-inflammatory drug. Strikingly, in a genetically engineered mouse model of HER-2/neu-induced mammary cancer, tumor penetrance in mice on a Western diet was nearly 50% by the age of 1 year whereas no tumors were detected in mice on the low CHO diet. This difference was associated with weight gains in mice on the Western diet not observed in mice on the low CHO diet. Moreover, whereas only 1 mouse on the Western diet achieved a normal life span, due to cancer-associated deaths, more than 50% of the mice on the low CHO diet reached or exceeded the normal life span. Taken together, our findings offer a compelling preclinical illustration of the ability of a low CHO diet in not only restricting weight gain but also cancer development and progression. Cancer Res; 71(13); 4484-93. ©2011 AACR.

PMID:
21673053

Link:
http://www.ncbi.nlm.nih.gov/pubmed?term=21673053

Posts [ 4 ] | Last post Aug. 4, 2011, 2:52 a.m.

#1 - July 1, 2011, 11:15 a.m.

BobbyBoomer

The main thing I don't like about this is the assumption about fat.

IMO this report says nothing about fat, only about carbohydrates.

I'd like to see them do it again with and without fat.

But then they would need to do omega 3s, omega 6s, etc.

Bobby

— Last Edited by BobbyBoomer at 2011-07-01 11:15:43 —

#2 - July 21, 2011, 4:59 p.m.

MikeMaybury

Why do all scientist use such cruel experiments on animals. The high protein diet is a totally unbalanced diet, disapproved of by most nutritionists. It is now claimed, on this flimsy evidence with mice, to help humans.
The Adventist studies, going back 50 years, have shown many times over, with real humans, that vegetarian diets are more likely that meat eating diets to reduce most cancers, as well as heart disease. The latest study, still ongoing, is studying over 100,000 people. That is a real group of real humans.
I am not an Adventist, but keep to much of their lifestyle recommendations. I eat a wholefood vegetarian diet, including regular intake of pulses, nuts, vegetables and fruits as well wholegrains. Combined with regular exercise this seems to work for me as well. At 76 I have no aches and pains and take no drugs, either legal or illegal, and life is fantastic. I have had ‘flu only once as an adult and only three colds in the last 15 years.
We’ll all die of something eventually, but to be healthy for most of your life seems to be a worthwhile thing to me. In only involves avoiding unnecessary chemicals and teatments and eating properly, which also avoids cruelty to animals!

— Last Edited by MikeMaybury at 2011-07-22 02:18:52 —

#3 - July 22, 2011, 2:06 a.m.

Anonymous

MikeMaybury;98083:

Why do most scientist use such cruel experiments on animals? This high protein and low carbohydrate diet a totally unbalanced diet, disapproved of by most nutritionists. It is now claimed, on this flimsy evidence with mice, to help humans.
The Adventist studies, going back 50 years, and still continuing, have shown many times over, with real humans, that vegetarian diets are more likely that meat-eating diets to reduce most cancers, as well as heart disease. The latest study, still ongoing, is studying over 100,000 people. That is a real group of real humans.
I am not an Adventist, but keep to much of their lifestyle recommendations. I eat a wholefood vegetarian diet, including regular intake of pulses, nut and vegetables and fruits as well wholegrains. Combined with regular exercise, this seems to work for me ery well. At76 I have no aches and pains and take no drugs, either legal or illegal, and life is fantastic. I've had ‘flu only once as an adult and few minor illnesses. Only 3 colds in the last 15 years.
We’ll all die of something eventually, but to be healthy for most of your life seems to be a worthwhile thing to me. It only involves avoiding unnecessary chemicals and teatments and eating properly, which also avoids cruelty to animals!

#4 - Aug. 4, 2011, 2:52 a.m.

Michealleo

hi i am on low carb diet right because of my crohnic disorder . But still Low carb diet helping me alots for managing my symptoms . hopefully it will help me to prevent the cancer too .