Image: Microscopy image showing (green) telomeres, the protective caps at the ends of (blue) chromosomes, which play a crucial role in cellular aging. Credit: Salk Institute
Scientists at the Salk Institute have debuted a new method for determining both the length and sequence of telomeres on individual chromosomes. Their breakthrough anti-aging and cancer telomere tech research published in Nature Communications reveals new insights into the dynamics of telomeres in health and disease. This innovation sets the stage for tracking telomere dynamics during aging and disease, as well as new discoveries that could transform health and longevity.
A new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers shows that an enzyme called PARP1 is involved in repair of telomeres, the lengths of DNA that protect the tips of chromosomes, and that impairing this process can lead to telomere shortening and genomic instability that can cause cancer.
Previous research suggests that restricting calories by 20-60% promotes a longer lifespan in animal studies. This two-year study of caloric restriction in humans found...
As we age, our bodies undergo countless changes. Some of these alterations are visible, such as wrinkles and gray hair, while others occur at the cellular level. One of the most intriguing cellular changes is the shortening of telomeres, which has been linked to aging and age-related diseases. But what are telomeres, and what is their connection to aging? In this article, we'll explore the role of telomeres in aging, their potential impact on our health, and what the future might hold for telomere research. Now let's dive into the fascinating world of telomers!
Changes in the brain caused by Alzheimer's disease are associated with shortening of the telomeres -- the protective caps on the ends of chromosomes that shorten as cells age -- according to a new study led by Anya Topiwala of Oxford Population Health, part of the University of Oxford, UK, published March 22 in the open-access journal PLOS ONE.
Telomeres are protective caps on DNA that shorten as we grow older. Now, one of the first studies to examine telomere length (TL) in childhood finds that the initial setting of TL during prenatal development and in the first years of life may determine one's TL throughout childhood and potentially even into adulthood or older age. The study also finds that TL decreases most rapidly from birth to age 3, followed by a period of maintenance into the pre-puberty period, although it was sometimes seen to lengthen.
Man Planck Institute researchers have shown when telomeres change length this results in changes being made to the structure of our brain.u00a0
Telomeres are the protective end caps on the ends of chromosomes, they help to keep the chromosomes from fraying or sticking together, but each time a cell a cell reproduces the telomeres gradually shorten until they become too short to function properly, and once no longer functional the cell becomes inactive or senescent.
Shortening of telomeres, the small structures at the ends of chromosomes, are proposed to be part of the reason we age. Telomeres help protect the genetic material inside DNA, with age they shorten with each cell division until they are not able to any longer; the longer the length of telomere the longer the lifespan.u00a0
Telomeres start to shorten even before you are born, and keep shortening with age. By middle age telomeres are significantly shorter, which is not good news for health.
Metformin & AMPK Link Nobel Prize-winning Telomeres & Jumping Genes with Learning, HIV, & the Creation of Human Life
https://www.linkedin.com/pulse/metformin-ampk-link-nobel-prize-winning-telomeres-jumping-finley/
Published on May 12, 2018
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Jahahreeh Finley
Patent Attorney and Founder | Finley BioSciences
40 articles
To be archived as per Dr.Klatz August 15.2018
