Clues Towards the Anti-Aging Pathway
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Posted on Jan 30, 2015, 6 a.m.
An experimental version of rapamycin boosted the immune system of seniors, revealing clues as to potential mechanisms for anti-aging drugs.
Rapamycin, a drug that targets a genetic signaling pathway linked to aging and immune function, has been studied in animal models for its potential use as an anti-aging therapeutic. A team from Novartis administered an experimental medication, a version of the drug rapamycin, to a group of older men and women. The subjects displayed an improved immune response to a flu vaccine of 20%. The study authors submit that: “These results raise the possibility that mTOR inhibition may have beneficial effects on immunosenescence in the elderly.”
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Joan B. Mannick, Giuseppe Del Giudice, Maria Lattanzi, Nicholas M. Valiante, Jens Praestgaard, et al. “mTOR inhibition improves immune function in the elderly.” Sci Transl Med Vol. 6, Issue 268, p. 268ra179.
